The Nerazzurri will host Los Blancos in round 4 of the UCL while PSG face RB Leipzig with the goal of bouncing back from their recent defeat to the Germans.

Headline fixture of UCL Matchday 4: Inter Milan vs Real Madrid

Real Madrid are gearing up for a crucial showdown with Inter Milan as Los Blancos look to return to winning ways when they visit the Nerazzurri. The last time these two sides faced off was on Matchday 3, with the Spaniards coming away with a 3-2 victory despite a late comeback attempt from the Serie A giants. However, things could turn out different this time around.

Since beating Antonio Conte's side, Zidane's men have failed to win their subsequent two games, losing 4-1 to Valencia right before the international break before drawing 1-1 with Villarreal upon their return. Another point of concern for Los Merengues is the injury to Ramos. The Spanish center-back is nursing a hamstring injury and will sit this one out. Given Real Madrid's horrible form in Europe when without their captain, the 13-time champions could struggle at San Siro.

As for Inter Milan, having gone four straight matches without a win from late October to November 8, they returned to winning ways with a 4-2 victory over Torino during the weekend. Conte's men had to comeback from 2-0 down to win the game thanks to a brace from Lukaku and goals from Lautaro Martinez and Alexis Sanchez. This is a confidence-boosting result that should have them hyped for Wednesday's European showdown.

Whoever loses this game will be bottom in the table – Inter currently occupy that spot but they can leapfrog third-placed Real Madrid with a win. Who will triumph in this fixture? Tune in to find out.

Key talking points ahead of Matchday 4

How will Barcelona fare in Dynamo Kyiv without Messi?

Barcelona have been struggling to perform this season. Hence, when Koeman announced his decision to leave Messi out of the squad to travel to Dynamo Kyiv, it came as a shock. While the Argentine has been far from his best this season, he has still contributed to 10 goals in 11 games for his club. It should be noted that the last time these two sides faced off at the Camp Nou, it was the Ukrainian giants that impressed despite the 2-1 loss. As a result, it will be interesting to see how the Blaugrana fare.

Who will secure qualification to the round of 16 on Matchday 4?

A total of seven teams can secure their spots in the knockout stage but only four can secure progression by simply beating their opponent and they are Barcelona, Liverpool, Bayern, and Man City. The remaining three – Juventus, Chelsea, and Sevilla – will need a win in the upcoming round but will also require the third-placed team to slip up in order to make the last 16 (in the case of Sevilla, they will need last-placed Rennes to draw or lose to the Blues.

Team news

Here are the key players who are definitely missing due to injury, suspension, or could be in doubt due to fitness or other issues and thus could miss out on upcoming matches for their respective sides heading into matchday 4:

Chelsea: Pulišić (hamstring); Havertz (doubt – match fitness), Gilmour (doubt – knee)

Barcelona: Piqué (knee), Roberto (thigh), Araújo (hamstring), Busquets (thigh), Fati (meniscus), Umtiti (match fitness), Messi (rested), De Jong (rested)

Juventus: Bonucci (thigh), Chiellini (thigh), Demiral (groin); Ramsey (doubt – thigh)

Man Utd: Shaw (hamstring), Lingard (illness); Bailly (doubt – muscular), Pogba (doubt – unspecified)

PSG: Kimpembe (suspended), Gueye (suspended), Bernat (knee), Draxler (thigh), Kehrer (groin), Icardi (knee); Herrera (doubt – calf), Verratti (doubt – thigh)

Atletico: Barinov (knee), Smolov (hamstring); Magkeev (doubt – hamstring), Ignatyev (doubt – calf)

Bayern: Davies (ankle), Kimmich (knee), Tolisso (muscle); Hernández (doubt – unspecified)

Inter: Brozović (illness), Kolarov (illness), Padelli (Illness), Sensi (thigh); Pinamonti (doubt – ankle)

Real Madrid: Valverde (tibia), Ramos (hamstring), Jović (illness); Militão (doubt – illness), Benzema (doubt – adductor), Odriozola (doubt – calf), Casemiro (doubt – illness)

Man City: Ake (hamstring); Fernandinho (doubt – illness)

Matchday 4 listings

Below are the fixtures set to take place on matchday 4: